Disfunzione cardiaca, aritmia e fibrosi epatica sono complicazioni ben observe dopo l’intervento chirurgico di bypass del cuore destro in pazienti con fisiologia a ventricolo singolo. Tuttavia, si sa poco sulle fistole arteriose coronariche e sono stati pubblicati solo pochi rapporti. Questo studio mirava a chiarire le caratteristiche cliniche di queste uncommon fistole arteriose coronariche che si sono sviluppate come complicanze nei casi di fisiologia del ventricolo singolo dopo un intervento di bypass cardiaco destro.
abbiamo studiato retrospettivamente le caratteristiche cliniche e il decorso dei pazienti che hanno sviluppato fistole arteriose coronariche acquisite e progressive dopo un intervento di bypass del cuore destro nel nostro ospedale. abbiamo identificato tre casi di fistole arteriose coronariche su 21 pazienti sottoposti a intervento chirurgico di bypass del cuore destro. Tutti e tre i casi sono stati sottoposti a cateterizzazione cardiaca per la valutazione post-operatoria e sono stati somministrati vasodilatatori polmonari di inibitori della fosfodiesterasi di tipo V, antiaggreganti piastrinici, anticoagulanti e diuretici. Inoltre, avevano caratteristiche cliniche comuni come il ventricolo singolo dominante destro e l’esposizione a lungo termine all’ipossia cronica.
i pazienti con ipossia cronica e ventricolo destro dominante, trattati con inibitori della fosfodiesterasi di tipo V, devono essere seguiti dopo un intervento chirurgico di bypass del cuore destro per monitorare il possibile sviluppo di fistole arteriose coronariche. Inoltre, l’indicazione per i vasodilatatori polmonari nella fisiologia del ventricolo singolo dopo un intervento chirurgico di bypass del cuore destro dovrebbe essere ottimizzata per evitare effetti avversi. Angiogrammi seriali hanno rivelato fistole arteriose coronariche acquisite e progressive. Inoltre, le fistole arteriose coronariche hanno contribuito ai loro sintomi di insufficienza cardiaca.
Il diabete mellito di tipo 1 (T1DM) può essere associato a deterioramento cognitivo e in particolare a un calo della velocità psicomotoria, della velocità di elaborazione delle informazioni e dell’attenzione. Il meccanismo di questo declino è incerto. Precedenti studi del nostro gruppo e di altri hanno dimostrato un declino della potenza EEG e dell’ampiezza potenziale correlata all’evento nel T1DM. Gli obiettivi del presente studio erano di esplorare se 1) l’associazione tra l’ampiezza del potenziale correlato all’evento (N100) e la velocità psicomotoria è diversa tra T1DM e soggetti sani, e 2) il declino dell’ampiezza N100 dipende dalla durata del diabete.
Analisi comparativa di morfologia, fisiologia fotosintetica e trascrittoma tra orzo diploide e tetraploide derivato da coltura microspore
I poliploidi svolgono un ruolo importante nell’allevamento di piante per caratteristiche superiori e molti rapporti si sono concentrati recentemente sugli effetti sulla fotosintesi della poliploidizzazione in alcune specie vegetali, ma sorprendentemente poco di questo è noto per l’orzo. In questo studio, piante omozigoti diploidi e tetraploidi, derivate dalla coltura microspore della cultivar d’orzo “H30”, sono state utilizzate per valutare le differenze tra loro nelle loro caratteristiche cellulari, fotosintetiche e trascrittomiche. I nostri risultati hanno mostrato che l’orzo tetraploide ha le caratteristiche distintive dei poliploidi, vale a dire foglie più spesse e più pesanti,
dimensioni degli stomi ingranditi o dimensioni delle cellule di guardia stomatiche e più pigmenti fotosintetici e fotosintesi migliorata (specialmente in condizioni di elevata intensità di luce). Questa migliore fotosintesi dell’orzo tetraploide è stata confermata da diversi parametri fotosintetici, tra cui velocità fotosintetica netta (Pn), conduttanza stomatica (Gs), concentrazione intercellulare di CO2 (Ci), velocità di traspirazione (Tr), velocità fotosintetica netta massima (Pmax), saturazione della luce punto (LSP), carbossilazione a velocità saturata RuBP massima (Vcmax) e velocità massima di trasporto di elettroni (Jmax).
Analisi trascrittomiche hanno rivelato che solo il 2,3% circa di tutti i geni rilevati mostrava modelli di espressione differenziale [cioè geni espressi differenzialmente (DEG)], e che la maggior parte di questi – 580 su 793 DEG in totale – erano sovraregolati nell’orzo tetraploide. L’analisi KEGG di follow-up ha indicato che il percorso più arricchito period correlato alle proteine dell’antenna della fotosintesi, mentre la sottoregolazione dei DEG period correlata principalmente al componente della proteina legante la colofia II a / b (Lhcb1) che raccoglieva la luce, entrambi convalidati mediante PCR quantitativa (qPCR). Nel loro insieme, la nostra analisi integrata di morfologia, fisiologia fotosintetica e trascrittoma fornisce show per la comprensione di come la poliploidizzazione migliora la capacità fotosintetica nei tetraploidi dell’orzo.

Il ruolo emergente del sistema apelinergico nella fisiologia e malattia renale
Il sistema apelinergico (AS) è un nuovo sistema pleiotropico con un ruolo essenziale nella fisiologia e malattia renale e cardiovascolare, inclusa l’omeostasi dell’acqua e la regolazione della pressione sanguigna. Consiste di due ligandi peptidici altamente conservati, apelin e apela, e un recettore dell’apelina accoppiato a proteine G. I due ligandi hanno molte isoforme e una breve emivita ed esercitano effetti sia simili che divergenti. La vasopressina, l’apelina ed i loro recettori colocalizzano nelle regioni ipotalamiche essenziali per l’omeostasi dei fluidi corporei e interagiscono a livello centrale e renale per regolare l’omeostasi dell’acqua e la diuresi in direzioni inverse.
Cefuroxime Sodium |
C023-1G |
TOKU-E |
1 g |
EUR 121 |
Cefuroxime Sodium |
C023-5G |
TOKU-E |
5 g |
EUR 335 |
Thyroxine (Sodium salt) |
30-AT52 |
Fitzgerald |
1 gram |
EUR 352 |
Description: High purity Thyroxine sodium salt |
Triiodothyronine (Sodium salt) |
30-AT53 |
Fitzgerald |
1 gram |
EUR 849 |
Description: High purity (>99%) Triiodothyronine sodium salt |
Nigericin sodium salt |
2096-25 |
Biovision |
|
EUR 387 |
Nigericin sodium salt |
2096-5 |
Biovision |
|
EUR 147 |
NADP, sodium salt |
2737-1000 |
Biovision |
|
EUR 784 |
Resazurin, sodium salt |
10054 |
Biotium |
10MG |
EUR 148 |
Description: Minimum order quantity: 1 unit of 10MG |
Novobiocin Sodium Salt |
B1526-1G |
Biovision |
|
EUR 109 |
Novobiocin Sodium Salt |
B1526-5G |
Biovision |
|
EUR 240 |
Cefazolin Sodium Salt |
B1530-1G |
Biovision |
|
EUR 142 |
Cefazolin Sodium Salt |
B1530-5G |
Biovision |
|
EUR 359 |
Cefoxitin Sodium Salt |
B1892-1G |
Biovision |
|
EUR 185 |
Cefoxitin Sodium Salt |
B1892-500 |
Biovision |
|
EUR 131 |
Cefoxitin Sodium Salt |
B1892-5G |
Biovision |
|
EUR 577 |
Azlocillin sodium salt |
B1893-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 108 |
Description: Azlocillin is an acylampicillin with a broad spectrum against bacteria. |
Azlocillin sodium salt |
B1893-50 |
ApexBio |
50 mg |
EUR 128 |
Description: Azlocillin is an acylampicillin with a broad spectrum against bacteria. |
Azlocillin sodium salt |
B1893-S |
ApexBio |
Evaluation Sample |
EUR 81 |
Description: Azlocillin is an acylampicillin with a broad spectrum against bacteria. |
Sulfamerazine sodium salt |
B3430-100000 |
ApexBio |
100 g |
EUR 137 |
Description: Sulfamerazine Sodium is a sulfonamide antibacterial. |
Sulfamerazine sodium salt |
B3430-50000 |
ApexBio |
50 g |
EUR 110 |
Description: Sulfamerazine Sodium is a sulfonamide antibacterial. |
GSK2190915 sodium salt |
B4905-10 |
ApexBio |
10 mg |
EUR 429 |
GSK2190915 sodium salt |
B4905-5 |
ApexBio |
5 mg |
EUR 277 |
GSK2190915 sodium salt |
B4905-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 380 |
GSK2190915 sodium salt |
B4905-50 |
ApexBio |
50 mg |
EUR 1549 |
Ischemin sodium salt |
B4917-10 |
ApexBio |
10 mg |
EUR 268 |
Ischemin sodium salt |
B4917-50 |
ApexBio |
50 mg |
EUR 973 |
Proglumide sodium salt |
B5121-100 |
ApexBio |
100 mg |
EUR 139 |
Proglumide sodium salt |
B5121-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 150 |
Entacapone sodium salt |
B1090-10 |
ApexBio |
10 mg |
EUR 139 |
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds. |
Entacapone sodium salt |
B1090-100 |
ApexBio |
100 mg |
EUR 321 |
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds. |
Entacapone sodium salt |
B1090-50 |
ApexBio |
50 mg |
EUR 231 |
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds. |
Adapalene sodium salt |
B1277-100 |
ApexBio |
100 mg |
EUR 142 |
Description: Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR). |
Adapalene sodium salt |
B1277-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 108 |
Description: Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR). |
Adapalene sodium salt |
B1277-50 |
ApexBio |
50 mg |
EUR 108 |
Description: Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR). |
GSK1349572 sodiuM salt |
B5856-10 |
ApexBio |
10 mg |
EUR 316 |
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor. |
GSK1349572 sodiuM salt |
B5856-100 |
ApexBio |
100 mg |
EUR 1210 |
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor. |
GSK1349572 sodiuM salt |
B5856-5 |
ApexBio |
5 mg |
EUR 241 |
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor. |
GSK1349572 sodiuM salt |
B5856-50 |
ApexBio |
50 mg |
EUR 728 |
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor. |
Resazurin sodium salt |
B6098-1000 |
ApexBio |
1 g |
EUR 84 |
Description: The non-fluorescent resazurin has been used as a fluorogenic oxidation-reduction indicator in various cells by flow cytometry, fluorescence microscopy and high-throughput screening. Its red-fluorescent product, resorufin, has absorption/emission maxima ~575/585 nm. |
Resazurin sodium salt |
B6098-5000 |
ApexBio |
5 g |
EUR 166 |
Description: The non-fluorescent resazurin has been used as a fluorogenic oxidation-reduction indicator in various cells by flow cytometry, fluorescence microscopy and high-throughput screening. Its red-fluorescent product, resorufin, has absorption/emission maxima ~575/585 nm. |
Dantrolene, sodium salt |
B6329-100 |
ApexBio |
100 mg |
EUR 132 |
Dantrolene, sodium salt |
B6329-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 108 |
Cefotaxime Sodium Salt |
abx188641-100g |
Abbexa |
100 g |
EUR 509 |
- Shipped within 1-2 weeks.
|
Tianeptine Sodium Salt |
abx188914-25g |
Abbexa |
25 g |
EUR 314 |
- Shipped within 1-2 weeks.
|
Cefotaxime Sodium Salt |
20-abx082178 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
PIPES Sodium Salt |
20-abx082438 |
Abbexa |
|
|
- Shipped within 5-10 working days.
|
Carboxymethylcellulose sodium salt |
abx082467-100g |
Abbexa |
100 g |
EUR 189 |
- Shipped within 5-10 working days.
|
Ampicillin Sodium Salt |
abx082587-5g |
Abbexa |
5 g |
EUR 175 |
- Shipped within 5-10 working days.
|
Fosmidomycin (sodium salt) |
C4898-10 |
ApexBio |
10 mg |
EUR 415 |
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces. |
Fosmidomycin (sodium salt) |
C4898-25 |
ApexBio |
25 mg |
EUR 830 |
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces. |
Fosmidomycin (sodium salt) |
C4898-5 |
ApexBio |
5 mg |
EUR 244 |
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces. |
Cefsulodin (sodium salt) |
C5593-1000 |
ApexBio |
1 g |
EUR 224 |
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1]. |
Cefsulodin (sodium salt) |
C5593-250 |
ApexBio |
250 mg |
EUR 123 |
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1]. |
Cefsulodin (sodium salt) |
C5593-500 |
ApexBio |
500 mg |
EUR 180 |
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1]. |
Furegrelate (sodium salt) |
C5692-10 |
ApexBio |
10 mg |
EUR 170 |
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2. |
Furegrelate (sodium salt) |
C5692-5 |
ApexBio |
5 mg |
EUR 112 |
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2. |
Furegrelate (sodium salt) |
C5692-50 |
ApexBio |
50 mg |
EUR 551 |
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2. |
Hepes, Sodium Salt |
CH039 |
ABM |
25 g |
EUR 118 |
Hepes, Sodium Salt |
CH040 |
ABM |
100 g |
EUR 169 |
Hepes, Sodium Salt |
CH041 |
ABM |
500 g |
EUR 374 |
Lorglumide (sodium salt) |
C4809-25 |
ApexBio |
25 mg |
EUR 145 |
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] . |
Lorglumide (sodium salt) |
C4809-50 |
ApexBio |
50 mg |
EUR 171 |
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] . |
Cefoxitin (sodium salt) |
C4849-1000 |
ApexBio |
1 g |
EUR 241 |
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. |
Cefoxitin (sodium salt) |
C4849-250 |
ApexBio |
250 mg |
EUR 113 |
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. |
Cefoxitin (sodium salt) |
C4849-500 |
ApexBio |
500 mg |
EUR 164 |
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2]. |
Cefamandole sodium salt |
C079-100MG |
TOKU-E |
100 mg |
EUR 148 |
Cefamandole sodium salt |
C079-500MG |
TOKU-E |
500 mg |
EUR 474 |
Moxalactam (sodium salt) |
C4121-1000 |
ApexBio |
1 g |
EUR 225 |
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
Moxalactam (sodium salt) |
C4121-250 |
ApexBio |
250 mg |
EUR 112 |
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
Moxalactam (sodium salt) |
C4121-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
Moxalactam (sodium salt) |
C4121-500 |
ApexBio |
500 mg |
EUR 168 |
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis. |
Cefazolin (sodium salt) |
C4183-1000 |
ApexBio |
1 g |
EUR 168 |
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
Cefazolin (sodium salt) |
C4183-250 |
ApexBio |
250 mg |
EUR 105 |
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
Cefazolin (sodium salt) |
C4183-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
Cefazolin (sodium salt) |
C4183-500 |
ApexBio |
500 mg |
EUR 138 |
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1]. |
Tazobactam (sodium salt) |
C4245-1000 |
ApexBio |
1 g |
EUR 226 |
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. |
Tazobactam (sodium salt) |
C4245-250 |
ApexBio |
250 mg |
EUR 116 |
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. |
Tazobactam (sodium salt) |
C4245-500 |
ApexBio |
500 mg |
EUR 168 |
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems. |
Simvastatin (sodium salt) |
C4426-100 |
ApexBio |
100 mg |
EUR 392 |
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs. |
Simvastatin (sodium salt) |
C4426-25 |
ApexBio |
25 mg |
EUR 196 |
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs. |
Moniliformin (sodium salt) |
C4459-1 |
ApexBio |
1 mg |
EUR 321 |
Description: Moniliformin induces mitotic arrest at the metaphase stage.Mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei. |
Cefotaxime (sodium salt) |
C4588-1000 |
ApexBio |
1 g |
EUR 126 |
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
Cefotaxime (sodium salt) |
C4588-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
Cefotaxime (sodium salt) |
C4588-500 |
ApexBio |
500 mg |
EUR 108 |
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
Cefotaxime (sodium salt) |
C4588-5000 |
ApexBio |
5 g |
EUR 151 |
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic. |
Methicillin (sodium salt) |
C3238-100 |
ApexBio |
100 mg |
EUR 145 |
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. |
Methicillin (sodium salt) |
C3238-250 |
ApexBio |
250 mg |
EUR 226 |
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. |
Methicillin (sodium salt) |
C3238-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. |
Methicillin (sodium salt) |
C3238-50 |
ApexBio |
50 mg |
EUR 108 |
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. |
Ertapenem (sodium salt) |
C3451-10 |
ApexBio |
10 mg |
EUR 241 |
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1]. |
Ertapenem (sodium salt) |
C3451-25 |
ApexBio |
25 mg |
EUR 448 |
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1]. |
Ertapenem (sodium salt) |
C3451-5 |
ApexBio |
5 mg |
EUR 163 |
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1]. |
Cefamandole (sodium salt) |
C3541-100 |
ApexBio |
100 mg |
EUR 244 |
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium". |
Cefamandole (sodium salt) |
C3541-50 |
ApexBio |
50 mg |
EUR 152 |
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium". |
Cefamandole (sodium salt) |
C3541-500 |
ApexBio |
500 mg |
EUR 592 |
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium". |
Narasin (sodium salt) |
C3061-25 |
ApexBio |
25 mg |
EUR 670 |
Description: IC50: 3.2 ?M: blocks NF-?B signaling via inhibition of I?B? phosphorylationNarasin, isolated from certain Streptomyces sp. is an ionophore antibiotic. |
Narasin (sodium salt) |
C3061-5 |
ApexBio |
5 mg |
EUR 187 |
Description: IC50: 3.2 ?M: blocks NF-?B signaling via inhibition of I?B? phosphorylationNarasin, isolated from certain Streptomyces sp. is an ionophore antibiotic. |
Cefonicid (sodium salt) |
C3812-1000 |
ApexBio |
1 g |
EUR 406 |
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins. |
Cefonicid (sodium salt) |
C3812-5.1 |
ApexBio |
10 mM (in 1mL DMSO) |
EUR 113 |
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins. |
Cefonicid (sodium salt) |
C3812-500 |
ApexBio |
500 mg |
EUR 251 |
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins. |
Cefoperazone (sodium salt) |
C3913-10000 |
ApexBio |
10 g |
EUR 403 |
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1]. |
Cefoperazone (sodium salt) |
C3913-5000 |
ApexBio |
5 g |
EUR 267 |
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1]. |
(±)-Cloprostenol sodium salt |
B7004-1 |
ApexBio |
1 mg |
EUR 112 |
(±)-Cloprostenol sodium salt |
B7004-10 |
ApexBio |
10 mg |
EUR 363 |
(±)-Cloprostenol sodium salt |
B7004-5 |
ApexBio |
5 mg |
EUR 300 |
HEPES Sodium salt |
B7303-250000 |
ApexBio |
250 g |
EUR 286 |
CHPG Sodium salt |
B7475-10 |
ApexBio |
10 mg |
EUR 253 |
CHPG Sodium salt |
B7475-50 |
ApexBio |
50 mg |
EUR 902 |
Nigericin sodium salt |
B7644-10 |
ApexBio |
10 mg |
EUR 131 |
Description: Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane. |
Nigericin sodium salt |
B7644-25 |
ApexBio |
25 mg |
EUR 212 |
Description: Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane. |
Nigericin sodium salt |
B7644-5 |
ApexBio |
5 mg |
EUR 102 |
Description: Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane. |
Bialaphos (sodium salt) |
B7852-100 |
ApexBio |
100 mg |
EUR 241 |
Description: The antibiotic bialaphos (or SF1293) is a natural non-selective phytotoxin produced by Streptomyces hygroscopicus. Bialaphos is a tripeptide consisting of two L-alanine molecules and an L-glutamic acid analogue called phosphinothricin. |
Bialaphos (sodium salt) |
B7852-50 |
ApexBio |
50 mg |
EUR 180 |
Description: The antibiotic bialaphos (or SF1293) is a natural non-selective phytotoxin produced by Streptomyces hygroscopicus. Bialaphos is a tripeptide consisting of two L-alanine molecules and an L-glutamic acid analogue called phosphinothricin. |
Ampicillin Sodium Salt |
AK0839-0010 |
Akron Biotech |
10g |
Ask for price |
Ampicillin Sodium Salt |
AK0839-0025 |
Akron Biotech |
25g |
Ask for price |
Ampicillin Sodium Salt |
AK0839-0100 |
Akron Biotech |
100g |
Ask for price |
Ampicillin, Sodium Salt |
A4004-005 |
GenDepot |
5g |
EUR 93 |
Ampicillin, Sodium Salt |
A4004-025 |
GenDepot |
25g |
EUR 172 |
Ampicillin, Sodium Salt |
A4004-100 |
GenDepot |
100g |
EUR 309 |
Sivelestat sodium salt |
A4430-10 |
ApexBio |
10 mg |
EUR 171 |
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro. |
Sivelestat sodium salt |
A4430-25 |
ApexBio |
25 mg |
EUR 340 |
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro. |
Sivelestat sodium salt |
A4430-5 |
ApexBio |
5 mg |
EUR 118 |
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro. |
Sivelestat sodium salt |
A4430-50 |
ApexBio |
50 mg |
EUR 561 |
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro. |
Fostriecin sodium salt |
A4536-.1 |
ApexBio |
100 µg |
EUR 487 |
Description: IC50: Inhibit protein phosphatase types 2A (PP2A) and 4 (PP4) intensively with an IC50 of 1.5 nM and 3 nM respectively. Inhibit topoisomerase II (Topo II) and protein phosphatase type 1 (PP1) slightly with an IC50 of 40 ?M and 131 ?M respectively. |
Inoltre, il sistema AS e renina-angiotensina interagiscono sia a livello sistemico che a livello renale, con implicazioni per il sistema cardiovascolare. Recentemente è stato segnalato un ruolo per l’AS in diversi stati patologici, inclusi disturbi dell’equilibrio idrico e del sodio, ipertensione, insufficienza cardiaca, pre-eclampsia, danno renale acuto, sepsi e nefropatia diabetica. Inoltre, sono stati sviluppati diversi analoghi dell’apelina metabolicamente stabili, con potenziali applicazioni in numerous malattie. Esaminiamo qui ciò che è attualmente noto sulle funzioni fisiologiche dell’AS, concentrandosi sull’omeostasi renale, cardiovascolare e metabolica e sul ruolo dell’AS nelle malattie affiliate. Descriviamo anche diversi ostacoli e opportunità di ricerca degne dell’attenzione della comunità nefrologica.