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Fistole arteriose coronariche acquisite e progressive in pazienti con fisiologia a ventricolo singolo e trattati con vasodilatatori polmonari

Fistole arteriose coronariche acquisite e progressive in pazienti con fisiologia a ventricolo singolo e trattati con vasodilatatori polmonari

Posted on by Joel Hayes

Disfunzione cardiaca, aritmia e fibrosi epatica sono complicazioni ben observe dopo l’intervento chirurgico di bypass del cuore destro in pazienti con fisiologia a ventricolo singolo. Tuttavia, si sa poco sulle fistole arteriose coronariche e sono stati pubblicati solo pochi rapporti. Questo studio mirava a chiarire le caratteristiche cliniche di queste uncommon fistole arteriose coronariche che si sono sviluppate come complicanze nei casi di fisiologia del ventricolo singolo dopo un intervento di bypass cardiaco destro.

abbiamo studiato retrospettivamente le caratteristiche cliniche e il decorso dei pazienti che hanno sviluppato fistole arteriose coronariche acquisite e progressive dopo un intervento di bypass del cuore destro nel nostro ospedale. abbiamo identificato tre casi di fistole arteriose coronariche su 21 pazienti sottoposti a intervento chirurgico di bypass del cuore destro. Tutti e tre i casi sono stati sottoposti a cateterizzazione cardiaca per la valutazione post-operatoria e sono stati somministrati vasodilatatori polmonari di inibitori della fosfodiesterasi di tipo V, antiaggreganti piastrinici, anticoagulanti e diuretici. Inoltre, avevano caratteristiche cliniche comuni come il ventricolo singolo dominante destro e l’esposizione a lungo termine all’ipossia cronica.

i pazienti con ipossia cronica e ventricolo destro dominante, trattati con inibitori della fosfodiesterasi di tipo V, devono essere seguiti dopo un intervento chirurgico di bypass del cuore destro per monitorare il possibile sviluppo di fistole arteriose coronariche. Inoltre, l’indicazione per i vasodilatatori polmonari nella fisiologia del ventricolo singolo dopo un intervento chirurgico di bypass del cuore destro dovrebbe essere ottimizzata per evitare effetti avversi. Angiogrammi seriali hanno rivelato fistole arteriose coronariche acquisite e progressive. Inoltre, le fistole arteriose coronariche hanno contribuito ai loro sintomi di insufficienza cardiaca.

Il diabete mellito di tipo 1 (T1DM) può essere associato a deterioramento cognitivo e in particolare a un calo della velocità psicomotoria, della velocità di elaborazione delle informazioni e dell’attenzione. Il meccanismo di questo declino è incerto. Precedenti studi del nostro gruppo e di altri hanno dimostrato un declino della potenza EEG e dell’ampiezza potenziale correlata all’evento nel T1DM. Gli obiettivi del presente studio erano di esplorare se 1) l’associazione tra l’ampiezza del potenziale correlato all’evento (N100) e la velocità psicomotoria è diversa tra T1DM e soggetti sani, e 2) il declino dell’ampiezza N100 dipende dalla durata del diabete.

Analisi comparativa di morfologia, fisiologia fotosintetica e trascrittoma tra orzo diploide e tetraploide derivato da coltura microspore

I poliploidi svolgono un ruolo importante nell’allevamento di piante per caratteristiche superiori e molti rapporti si sono concentrati recentemente sugli effetti sulla fotosintesi della poliploidizzazione in alcune specie vegetali, ma sorprendentemente poco di questo è noto per l’orzo. In questo studio, piante omozigoti diploidi e tetraploidi, derivate dalla coltura microspore della cultivar d’orzo “H30”, sono state utilizzate per valutare le differenze tra loro nelle loro caratteristiche cellulari, fotosintetiche e trascrittomiche. I nostri risultati hanno mostrato che l’orzo tetraploide ha le caratteristiche distintive dei poliploidi, vale a dire foglie più spesse e più pesanti,

dimensioni degli stomi ingranditi o dimensioni delle cellule di guardia stomatiche e più pigmenti fotosintetici e fotosintesi migliorata (specialmente in condizioni di elevata intensità di luce). Questa migliore fotosintesi dell’orzo tetraploide è stata confermata da diversi parametri fotosintetici, tra cui velocità fotosintetica netta (Pn), conduttanza stomatica (Gs), concentrazione intercellulare di CO2 (Ci), velocità di traspirazione (Tr), velocità fotosintetica netta massima (Pmax), saturazione della luce punto (LSP), carbossilazione a velocità saturata RuBP massima (Vcmax) e velocità massima di trasporto di elettroni (Jmax).

Analisi trascrittomiche hanno rivelato che solo il 2,3% circa di tutti i geni rilevati mostrava modelli di espressione differenziale [cioè geni espressi differenzialmente (DEG)], e che la maggior parte di questi – 580 su 793 DEG in totale – erano sovraregolati nell’orzo tetraploide. L’analisi KEGG di follow-up ha indicato che il percorso più arricchito period correlato alle proteine ​​dell’antenna della fotosintesi, mentre la sottoregolazione dei DEG period correlata principalmente al componente della proteina legante la colofia II a / b (Lhcb1) che raccoglieva la luce, entrambi convalidati mediante PCR quantitativa (qPCR). Nel loro insieme, la nostra analisi integrata di morfologia, fisiologia fotosintetica e trascrittoma fornisce show per la comprensione di come la poliploidizzazione migliora la capacità fotosintetica nei tetraploidi dell’orzo.

Fistole arteriose coronariche acquisite e progressive in pazienti con fisiologia a ventricolo singolo e trattati con vasodilatatori polmonari

Il ruolo emergente del sistema apelinergico nella fisiologia e malattia renale

Il sistema apelinergico (AS) è un nuovo sistema pleiotropico con un ruolo essenziale nella fisiologia e malattia renale e cardiovascolare, inclusa l’omeostasi dell’acqua e la regolazione della pressione sanguigna. Consiste di due ligandi peptidici altamente conservati, apelin e apela, e un recettore dell’apelina accoppiato a proteine ​​G. I due ligandi hanno molte isoforme e una breve emivita ed esercitano effetti sia simili che divergenti. La vasopressina, l’apelina ed i loro recettori colocalizzano nelle regioni ipotalamiche essenziali per l’omeostasi dei fluidi corporei e interagiscono a livello centrale e renale per regolare l’omeostasi dell’acqua e la diuresi in direzioni inverse.

Cefuroxime Sodium
C023-1G 1 g
EUR 121

Cefuroxime Sodium
C023-5G 5 g
EUR 335

Cefuroxime (sodium)
HY-B1256 1g
EUR 160

Cefuroxime
GA9610-100MG 100 mg
EUR 70

Cefuroxime
GA9610-1G 1 g
EUR 156

Cefuroxime
GA9610-250MG 250 mg
EUR 94

Thyroxine (Sodium salt)
30-AT52 1 gram
EUR 352
Description: High purity Thyroxine sodium salt

Triiodothyronine (Sodium salt)
30-AT53 1 gram
EUR 849
Description: High purity (>99%) Triiodothyronine sodium salt

Nigericin sodium salt
2096-25
EUR 387

Nigericin sodium salt
2096-5
EUR 147

NADP, sodium salt
2737-100
EUR 153

NADP, sodium salt
2737-1000
EUR 784

NADP, sodium salt
2737-500
EUR 457

Resazurin, sodium salt
10054 10MG
EUR 148
Description: Minimum order quantity: 1 unit of 10MG

Novobiocin Sodium Salt
B1526-1G
EUR 109

Novobiocin Sodium Salt
B1526-5G
EUR 240

Cefazolin Sodium Salt
B1530-1G
EUR 142

Cefazolin Sodium Salt
B1530-5G
EUR 359

Cefoxitin Sodium Salt
B1892-1G
EUR 185

Cefoxitin Sodium Salt
B1892-500
EUR 131

Cefoxitin Sodium Salt
B1892-5G
EUR 577

Azlocillin sodium salt
B1893-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Azlocillin is an acylampicillin with a broad spectrum against bacteria.

Azlocillin sodium salt
B1893-50 50 mg
EUR 128
Description: Azlocillin is an acylampicillin with a broad spectrum against bacteria.

Azlocillin sodium salt
B1893-S Evaluation Sample
EUR 81
Description: Azlocillin is an acylampicillin with a broad spectrum against bacteria.

Sulfamerazine sodium salt
B3430-100000 100 g
EUR 137
Description: Sulfamerazine Sodium is a sulfonamide antibacterial.

Sulfamerazine sodium salt
B3430-50000 50 g
EUR 110
Description: Sulfamerazine Sodium is a sulfonamide antibacterial.

GSK2190915 sodium salt
B4905-10 10 mg
EUR 429

GSK2190915 sodium salt
B4905-5 5 mg
EUR 277

GSK2190915 sodium salt
B4905-5.1 10 mM (in 1mL DMSO)
EUR 380

GSK2190915 sodium salt
B4905-50 50 mg
EUR 1549

Ischemin sodium salt
B4917-10 10 mg
EUR 268

Ischemin sodium salt
B4917-50 50 mg
EUR 973

Proglumide sodium salt
B5121-100 100 mg
EUR 139

Proglumide sodium salt
B5121-5.1 10 mM (in 1mL DMSO)
EUR 150

Entacapone sodium salt
B1090-10 10 mg
EUR 139
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds.

Entacapone sodium salt
B1090-100 100 mg
EUR 321
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds.

Entacapone sodium salt
B1090-50 50 mg
EUR 231
Description: Entacapone, a nitrocatechol compound, is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), a Mg2+-dependent enzyme involved in the metabolism of catecholamines and catechol compounds.

Adapalene sodium salt
B1277-100 100 mg
EUR 142
Description: Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).

Adapalene sodium salt
B1277-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).

Adapalene sodium salt
B1277-50 50 mg
EUR 108
Description: Adapalene sodium salt, a synthetic retinoid, is a Retinoic acid receptor agonist (RAR).

GSK1349572 sodiuM salt
B5856-10 10 mg
EUR 316
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor.

GSK1349572 sodiuM salt
B5856-100 100 mg
EUR 1210
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor.

GSK1349572 sodiuM salt
B5856-5 5 mg
EUR 241
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor.

GSK1349572 sodiuM salt
B5856-50 50 mg
EUR 728
Description: Integrase inhibitors are a new class of antiretroviral drugs blocking the action of HIV integrase, which catalyses several key steps in the life cycle of the virus and is essential for insertion of the viral genome into the host cell DNA. GSK1349572 is a next-generation HIV integrase (IN) inhibitor.

Resazurin sodium salt
B6098-1000 1 g
EUR 84
Description: The non-fluorescent resazurin has been used as a fluorogenic oxidation-reduction indicator in various cells by flow cytometry, fluorescence microscopy and high-throughput screening. Its red-fluorescent product, resorufin, has absorption/emission maxima ~575/585 nm.

Resazurin sodium salt
B6098-5000 5 g
EUR 166
Description: The non-fluorescent resazurin has been used as a fluorogenic oxidation-reduction indicator in various cells by flow cytometry, fluorescence microscopy and high-throughput screening. Its red-fluorescent product, resorufin, has absorption/emission maxima ~575/585 nm.

Dantrolene, sodium salt
B6329-100 100 mg
EUR 132

Dantrolene, sodium salt
B6329-5.1 10 mM (in 1mL DMSO)
EUR 108

Cefotaxime Sodium Salt
abx188641-100g 100 g
EUR 509
  • Shipped within 1-2 weeks.

Tianeptine Sodium Salt
abx188914-25g 25 g
EUR 314
  • Shipped within 1-2 weeks.

Cefotaxime Sodium Salt
20-abx082178
  • EUR 217.00
  • EUR 175.00
  • 100 mg
  • 5 g
  • Shipped within 5-10 working days.

PIPES Sodium Salt
20-abx082438
  • EUR 272.00
  • EUR 189.00
  • 250 g
  • 25 g
  • Shipped within 5-10 working days.

Carboxymethylcellulose sodium salt
abx082467-100g 100 g
EUR 189
  • Shipped within 5-10 working days.

Ampicillin Sodium Salt
abx082587-5g 5 g
EUR 175
  • Shipped within 5-10 working days.

Fosmidomycin (sodium salt)
C4898-10 10 mg
EUR 415
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.

Fosmidomycin (sodium salt)
C4898-25 25 mg
EUR 830
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.

Fosmidomycin (sodium salt)
C4898-5 5 mg
EUR 244
Description: Fosmidomycin is a specific inhibitor of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXP) [1]. Fosmidomycin is an antibiotic originally isolated from bacteria of the genus Streptomyces.

Cefsulodin (sodium salt)
C5593-1000 1 g
EUR 224
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1].

Cefsulodin (sodium salt)
C5593-250 250 mg
EUR 123
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1].

Cefsulodin (sodium salt)
C5593-500 500 mg
EUR 180
Description: Cefsulodin, formerly named as SCE-129, is a cephalosporin with a spectrum of antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and most other gram-positive cocci [1].

Furegrelate (sodium salt)
C5692-10 10 mg
EUR 170
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2.

Furegrelate (sodium salt)
C5692-5 5 mg
EUR 112
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2.

Furegrelate (sodium salt)
C5692-50 50 mg
EUR 551
Description: Furegrelate (sodium salt) is a potent inhibitor of thromboxane synthase [1][2].Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) is a cytochrome P450 enzyme that catalyzes the conversion of prostaglandin H2 to thromboxane A2.

Hepes, Sodium Salt
CH039 25 g
EUR 118

Hepes, Sodium Salt
CH040 100 g
EUR 169

Hepes, Sodium Salt
CH041 500 g
EUR 374

Lorglumide (sodium salt)
C4809-25 25 mg
EUR 145
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] .

Lorglumide (sodium salt)
C4809-50 50 mg
EUR 171
Description: Lorglumide (sodium salt) is the first nonpeptidic, selective and potent inhibitor of the CCK-A receptor [1][2][3][4] .

Cefoxitin (sodium salt)
C4849-1000 1 g
EUR 241
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Cefoxitin (sodium salt)
C4849-250 250 mg
EUR 113
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Cefoxitin (sodium salt)
C4849-500 500 mg
EUR 164
Description: Cefoxitin (sodium salt) is a second generation cephalosporin antibiotic that was used to treat a wide range of gram-negative and gram-positive bacteria [1][2].

Cefamandole sodium salt
C079-100MG 100 mg
EUR 148

Cefamandole sodium salt
C079-500MG 500 mg
EUR 474

Moxalactam (sodium salt)
C4121-1000 1 g
EUR 225
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.

Moxalactam (sodium salt)
C4121-250 250 mg
EUR 112
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.

Moxalactam (sodium salt)
C4121-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.

Moxalactam (sodium salt)
C4121-500 500 mg
EUR 168
Description: Moxalactam (sodium salt) is a ?-lactam antibiotic.?-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. Most ?-lactam antibiotics act by inhibiting cell wall biosynthesis.

Cefazolin (sodium salt)
C4183-1000 1 g
EUR 168
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefazolin (sodium salt)
C4183-250 250 mg
EUR 105
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefazolin (sodium salt)
C4183-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Cefazolin (sodium salt)
C4183-500 500 mg
EUR 138
Description: Cefazolin is a semisynthetic antibiotic with a broad spectrum of antibacterial activity. Cefazolin has exhibited high activity against Gram-positive bacteria and Gram-negative bacteria [1].

Tazobactam (sodium salt)
C4245-1000 1 g
EUR 226
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.

Tazobactam (sodium salt)
C4245-250 250 mg
EUR 116
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.

Tazobactam (sodium salt)
C4245-500 500 mg
EUR 168
Description: Tazobactam is a ?-lactamase inhibitor [1]. Tazobactam shows intrinsic activity against Acinetobacter strains. The ?-Lactamases are responsible for resistance to penicillins, extended-spectrum cephalosporins, monobactams, and carbapenems.

Simvastatin (sodium salt)
C4426-100 100 mg
EUR 392
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs.

Simvastatin (sodium salt)
C4426-25 25 mg
EUR 196
Description: Ki: 0.12 nMSimvastatin is a HMG-CoA reductase inhibitor. HMG-CoA reductase has been found to be the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the ?statin? class of cholesterol-lowering drugs.

Moniliformin (sodium salt)
C4459-1 1 mg
EUR 321
Description: Moniliformin induces mitotic arrest at the metaphase stage.Mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei.

Cefotaxime (sodium salt)
C4588-1000 1 g
EUR 126
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime (sodium salt)
C4588-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime (sodium salt)
C4588-500 500 mg
EUR 108
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Cefotaxime (sodium salt)
C4588-5000 5 g
EUR 151
Description: MIC: <0.1 ?g/ml for S. pneumoniae Cefotaxime is a cephalosporin antibiotic.

Methicillin (sodium salt)
C3238-100 100 mg
EUR 145
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls.

Methicillin (sodium salt)
C3238-250 250 mg
EUR 226
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls.

Methicillin (sodium salt)
C3238-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls.

Methicillin (sodium salt)
C3238-50 50 mg
EUR 108
Description: Methicillin is a semisynthetic penicillin antibiotic.In vitro: Similar to other ?-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls.

Ertapenem (sodium salt)
C3451-10 10 mg
EUR 241
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1].

Ertapenem (sodium salt)
C3451-25 25 mg
EUR 448
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1].

Ertapenem (sodium salt)
C3451-5 5 mg
EUR 163
Description: Ertapenem, the first group of carbapenems, is a 1-?-methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram-positive and Gram-negative aerobic and anaerobic pathogens [1].

Cefamandole (sodium salt)
C3541-100 100 mg
EUR 244
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

Cefamandole (sodium salt)
C3541-50 50 mg
EUR 152
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

Cefamandole (sodium salt)
C3541-500 500 mg
EUR 592
Description: MIC: 0.25-2 mg/L for different E. coli strainsCefamandole is a cephalosporin antibiotic.The cephalosporins are a class of ?-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

Narasin (sodium salt)
C3061-25 25 mg
EUR 670
Description: IC50: 3.2 ?M: blocks NF-?B signaling via inhibition of I?B? phosphorylationNarasin, isolated from certain Streptomyces sp. is an ionophore antibiotic.

Narasin (sodium salt)
C3061-5 5 mg
EUR 187
Description: IC50: 3.2 ?M: blocks NF-?B signaling via inhibition of I?B? phosphorylationNarasin, isolated from certain Streptomyces sp. is an ionophore antibiotic.

Cefonicid (sodium salt)
C3812-1000 1 g
EUR 406
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

Cefonicid (sodium salt)
C3812-5.1 10 mM (in 1mL DMSO)
EUR 113
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

Cefonicid (sodium salt)
C3812-500 500 mg
EUR 251
Description: Cefonicid is a second-generation cephalosporin antibiotic.Cephalosporins, the largest and most diverse family of antibiotics of the beta-lactam group, are structurally and pharmacologically related to the penicillins.

Cefoperazone (sodium salt)
C3913-10000 10 g
EUR 403
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].

Cefoperazone (sodium salt)
C3913-5000 5 g
EUR 267
Description: Cefoperazone is a new semisynthetic cephalosporin with a broad spectrum of antibacterial activity. Cefoperazone shows high activity against gram-positive bacteria and gram-negative bacilli, such as Escherichia coli, Klebsiella pneumoniae, and Proteus species [1].

(±)-Cloprostenol sodium salt
B7004-1 1 mg
EUR 112

(±)-Cloprostenol sodium salt
B7004-10 10 mg
EUR 363

(±)-Cloprostenol sodium salt
B7004-5 5 mg
EUR 300

HEPES Sodium salt
B7303-250000 250 g
EUR 286

CHPG Sodium salt
B7475-10 10 mg
EUR 253

CHPG Sodium salt
B7475-50 50 mg
EUR 902

Nigericin sodium salt
B7644-10 10 mg
EUR 131
Description: Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane.

Nigericin sodium salt
B7644-25 25 mg
EUR 212
Description: Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane.

Nigericin sodium salt
B7644-5 5 mg
EUR 102
Description: Nigericin sodium salt is an ionophore that exchanges K+ for H+ across biological membranes.Ionophore is a lipid-soluble molecule that transports ions across the cell membrane.

Bialaphos (sodium salt)
B7852-100 100 mg
EUR 241
Description: The antibiotic bialaphos (or SF1293) is a natural non-selective phytotoxin produced by Streptomyces hygroscopicus. Bialaphos is a tripeptide consisting of two L-alanine molecules and an L-glutamic acid analogue called phosphinothricin.

Bialaphos (sodium salt)
B7852-50 50 mg
EUR 180
Description: The antibiotic bialaphos (or SF1293) is a natural non-selective phytotoxin produced by Streptomyces hygroscopicus. Bialaphos is a tripeptide consisting of two L-alanine molecules and an L-glutamic acid analogue called phosphinothricin.

Ampicillin Sodium Salt
AK0839-0010 10g Ask for price

Ampicillin Sodium Salt
AK0839-0025 25g Ask for price

Ampicillin Sodium Salt
AK0839-0100 100g Ask for price

Heparin Sodium Salt
AK3004-1000 1g Ask for price

Heparin Sodium Salt
AK3004-5000 5g Ask for price

Ampicillin, Sodium Salt
A4004-005 5g
EUR 93

Ampicillin, Sodium Salt
A4004-025 25g
EUR 172

Ampicillin, Sodium Salt
A4004-100 100g
EUR 309

Sivelestat sodium salt
A4430-10 10 mg
EUR 171
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro.

Sivelestat sodium salt
A4430-25 25 mg
EUR 340
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro.

Sivelestat sodium salt
A4430-5 5 mg
EUR 118
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro.

Sivelestat sodium salt
A4430-50 50 mg
EUR 561
Description: Selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. Inhibits NF-?B activation and LTB4-induced neutrophil transmigration in vitro.

Fostriecin sodium salt
A4536-.1 100 µg
EUR 487
Description: IC50: Inhibit protein phosphatase types 2A (PP2A) and 4 (PP4) intensively with an IC50 of 1.5 nM and 3 nM respectively. Inhibit topoisomerase II (Topo II) and protein phosphatase type 1 (PP1) slightly with an IC50 of 40 ?M and 131 ?M respectively.

Inoltre, il sistema AS e renina-angiotensina interagiscono sia a livello sistemico che a livello renale, con implicazioni per il sistema cardiovascolare. Recentemente è stato segnalato un ruolo per l’AS in diversi stati patologici, inclusi disturbi dell’equilibrio idrico e del sodio, ipertensione, insufficienza cardiaca, pre-eclampsia, danno renale acuto, sepsi e nefropatia diabetica. Inoltre, sono stati sviluppati diversi analoghi dell’apelina metabolicamente stabili, con potenziali applicazioni in numerous malattie. Esaminiamo qui ciò che è attualmente noto sulle funzioni fisiologiche dell’AS, concentrandosi sull’omeostasi renale, cardiovascolare e metabolica e sul ruolo dell’AS nelle malattie affiliate. Descriviamo anche diversi ostacoli e opportunità di ricerca degne dell’attenzione della comunità nefrologica.